Key result
Pre-operative statin use in non-cardiac vascular surgery may decrease hospitalization duration, reduce postoperative infections, and prevent peri-operative arrhythmias.
Why the study?
Does pre-operative statin use improve outcomes in patients undergoing non-cardiac vascular surgery?
Does pre-operative statin use improve outcomes in patients undergoing non-cardiac vascular surgery?
Pre-operative statin use in non-cardiac vascular surgery may offer additional benefits such as reduced hospital stay, fewer infections, and prevention of peri-operative arrhythmias.
Biccard evaluated the benefits associated with pre-operative statin use in patients undergoing non-cardiac vascular surgery [1]. A few additional comments may be of interest: In some studies, pre-operative statin treatment is associated with a significant decrease in the postoperative duration of hospitalisation compared with placebo in patients undergoing non-cardiac vascular surgery [2-4]. In turn, the length of hospital stay is associated with an increased risk of infection [5, 6]. In addition, preliminary evidence suggests that preoperative statin use is independently associated with a reduction in postoperative infections [7]. Statins may prevent peri-operative arrhythmias (e.g. atrial fibrillation) [8, 9]. The above-mentioned beneficial effects, if confirmed, could make statins an essential component of peri-operative medical management. However, there may be ethical limitations in designing appropriate trials to provide definitive answers.
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Paraskevas et al. (2008) conducted a letter in Non-cardiac vascular surgery. Pre-operative statin use vs. Placebo was evaluated. Pre-operative statin use in non-cardiac vascular surgery may decrease hospitalization duration, reduce postoperative infections, and prevent peri-operative arrhythmias.
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