The most highly replicated asthma susceptibility locus, chromosome 17q21, houses three genes, one of which encodes ORMDL3, a protein that can inhibit the production of sphingolipids. Decreased sphingolipid synthesis disrupts magnesium homeostasis and increases airway hyperreactivity — a major diagnostic criterion for asthma.
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Bruce David Levy (2013) studied this question.
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