Plasma Cell Orificial Mucositis

• Plasma cell orificial mucositis is a benign idiopathic condition of orificial mucous membranes, characterized histopathologically by a dense plasmacytic infiltrate. Although plasma cell orificial mucositis was originally described by Zoon1as occurring on the glans penis, conditions similar to plasma cell orificial mucositis involving other body orifices have been reported under various names. A patient with involvement of the lips and epiglottis associated with psoriasis and fissured tongue is described. Plasma cell orificial mucositis must be differentiated from numerous other entities, including erythroplasia of Queyrat, allergic contact mucositis, plasmacytoma, plasmoacanthoma, syphilis, candidiasis, and cheilitis granulomatosa. (Arch Dermatol1986;122:1321-1324)