Article Abstract Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text. Many depressed patients do not remit on antidepressant medication despite an adequate dosage and a sufficient duration of treatment. This has spawned endeavors to define treatment-resistant depression as a depressive episode that has shown insufficient response to 1 or more adequate trials of an antidepressant. What constitutes insufficient, inadequate, or partial response is still a matter of debate.
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Desseilles et al. (2011) studied this question.
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