The Role ofH. pyloriCagA in Regulating Hormones of Functional Dyspepsia Patients

This is the authors' abstract. We don't add key points for this paper.

Helicobacter pylori(H. pylori, Hp) colonizes the stomachs of approximately 20%–80% of humans throughout the world. The Word Healthy Organization (WHO) classifiedH. pylorias a group 1 carcinogenic factor in 1994. Recently, an increasing number of studies has shown an association betweenH. pyloriinfection and various extragastric diseases. Functional dyspepsia (FD) is considered a biopsychosocial disorder with multifactorial pathogenesis, and studies have shown that infection with CagA-positiveH. pyloristrains could explain some of the symptoms of functional dyspepsia. Moreover, CagA-positiveH. pyloristrains have been shown to affect the secretion of several hormones, including 5-HT, ghrelin, dopamine, and gastrin, and altered levels of these hormones might be the cause of the psychological disorders of functional dyspepsia patients. This review describes the mutual effects ofH. pyloriand hormones in functional dyspepsia and provides new insight into the pathogenesis of functional dyspepsia.