BACKGROUND AND OBJECTIVES: Outpatient low-dose buprenorphine initiation (LDBI) is challenging for individuals with severe mental illness and poor treatment adherence. Visiting nurse services (VNS) may support LDBI in these complex patients. METHODS: We present a 64-year-old male with opioid use disorder, schizoaffective disorder, and post-traumatic stress disorder who underwent outpatient LDBI supported by VNS. RESULTS: VNS managed medication administration and adherence monitoring, facilitating successful LDBI and sustained engagement. DISCUSSION AND CONCLUSIONS: VNS facilitated outpatient LDBI and buprenorphine treatment engagement in a patient with fluctuating psychiatric illness and ongoing fentanyl use. SCIENTIFIC SIGNIFICANCE: This case suggests that VNS may facilitate outpatient LDBI and engagement among clinically complex patients in the fentanyl era.
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