Norcrassin A and norcrocrassinone are C16 tetranorditerpenoids featuring unique polycyclic frameworks. Herein, we detail a seven-step synthesis of the BC-bicyclic lactone common to both natural products. Key reactions include a SO3-mediated allylic alcohol transposition, Johnson–Claisen rearrangement, and an epoxide ring-opening/lactonization sequence.
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Nguyen et al. (2026) studied this question.
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