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Atropine is often used to counteract bradycardia after acute inferior-wall myocardial infarction, but its value needs careful reassessment due to untoward effects.
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A 1974 letter to the editor highlighting the need to reassess the use of atropine for bradycardia complicating acute inferior-wall myocardial infarction due to potential untoward effects.
Letters1 July 1974Atropine and Bradycardia After Myocardial InfarctionNICHOLAS G. KOUNIS, M.D., R. K. CHOPRA, M.B., B.S.NICHOLAS G. KOUNIS, M.D., R. K. CHOPRA, M.B., B.S.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-1-117 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: It is known that acute inferior-wall myocardial infarction is accompanied by sinus or nodal bradycardia, which often is caused either by excessive parasympathetic activity because of stimulation of vagal nerve endings in the posterior part of the atrioventricular groove (1) or the release of depressor substances, such as adenosine (2). The resulting slow ventricular rate leads to a low cardiac output, with consequent hypotension and poor tissue perfusion, which aggravates the myocardial ischemia. Atropine is often used to counteract these complications, but it has some untoward effects, and therefore its value needs careful reassessment.We did a...References1. JAMES T: The coronary circulation and conduction system in acute myocardial infarction. Prog Cardiovasc Dis 10:410-449, 1968 CrossrefMedlineGoogle Scholar2. JAMES T: The chronotropic action of A.T.P. and related compounds studied by direct perfusion of the sinus node. J Pharmacol Ther 149:233-247, 1965 MedlineGoogle Scholar3. ARMSTRONGDUNCANOLIVER ABM: Natural history of acute coronary heart attack. A community study. Br Heart J 34:67-80, 1972 CrossrefMedlineGoogle Scholar4. GOODMANGILMAN LA: The Pharmacological Basis of Therapeutics, 4th ed. New York, The Macmillan Company, 1970, p. 530 Google Scholar5. RIGHTMIERHARWOOD DB: Atropine-induced bradycardia (letter). N Engl J Med 289:1039, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Walton Hospital Liverpool L91AE England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Evolution of Modern Medicine: Garden to Pill BoxParasympathikolytika und SympathikomimetikaThe effect of atropine on cardiac arrhythmias and conduction. Part 1Effects of atropine in patients with bradyarrhythmia complicating myocardial infarctionBeneficial effects of atropine in the pre-hospital phase of coronary careUse of atropine in patients with acute myocardial infarction and sinus bradycardia. 1 July 1974Volume 81, Issue 1Page: 117-118KeywordsAdenosineAtropineBradycardiaCardiac outputHypotensionIschemiaMyocardial infarctionNerve endings Issue Published: 1 July 1974 PDF downloadLoading ...
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Nicholas George Kounis (1974) conducted a letter in Acute inferior-wall myocardial infarction with bradycardia. Atropine was evaluated. Atropine is often used to counteract bradycardia after acute inferior-wall myocardial infarction, but its value needs careful reassessment due to untoward effects.
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