Amyloid‐Beta Peptide Forms Monomeric Complexes With CuII and ZnII Prior to Aggregation

Brief encounter. ZnII- and CuII-induced aggregation of the peptide amyloid-β (Aβ) are considered to be involved in Alzheimer's disease. The present data indicate that ZnII and CuII transiently form a monomeric complex with Aβ40/42 before aggregation, which exhibits no further transiently stable intermediate up to ∼15-mer.