Key result
Warfarin therapy linked to ~2.5-fold higher prevalence of tracheobronchial cartilage calcification.
Why the study?
Progressive calcification of tracheal and bronchial cartilaginous rings has been observed in patients undergoing prolonged warfarin sodium therapy, but the relationship needed validation.
Does prolonged warfarin sodium therapy increase the risk of calcification of the cartilaginous rings of the trachea and bronchi compared to a control group?
Observational (n=197)
Does prolonged warfarin sodium therapy increase the risk of calcification of the cartilaginous rings of the trachea and bronchi compared to a control group?
Absolute Event Rate: 47% vs 19%
p-value: p=<0.001
Prolonged warfarin therapy is significantly associated with increased calcification of the tracheal and bronchial cartilaginous rings, with a positive correlation between therapy duration and calcification severity.
No takes yet. Share an insight, caveat, or question.
May prompt awareness of airway calcification on imaging in warfarin patients; leaves open causality and clinical relevance.
Moncada et al. (1992) conducted an observational in Calcification of the cartilaginous rings of the trachea and bronchi (n=197). Warfarin sodium therapy vs. Control group was evaluated on Presence of subtle (level 1) or extensive (level 2) calcification of the cartilaginous rings (CCR) (p=<0.001). Warfarin sodium therapy was associated with a significantly higher prevalence of tracheal and bronchial cartilaginous ring calcification compared to controls (47% vs 19%, P<0.001).
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