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The frequency of drowsiness attributed to orally administered chlorpromazine hydrochloride was compared among 130 nonsmokers and 201 "light" and 72 "heavy" cigarette smokers. Drowsiness occurred in 16%, 11%, and 3%, respectively. More rapid metabolism of chlorpromazine in cigarette smokers may explain these findings.
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Chester P. Swett (1974) studied this question.
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