Stretched cavity-assisted molding of particles is a novel method that can produce monodisperse submicrometer hydrogel particles (see image) loaded with a model protein drug, fluorescein-isothiocyanate-conjugated bovine serum albumin. The method avoids agitation, solvents, and high-energy input by forming the particles inside preformed cavities. This method has the potential to be generalized to prepare multilayered or targeted particles containing fragile drugs for the pharmaceutical industry.
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Laulia et al. (2007) studied this question.
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