Key result
Infarct-related artery perfusion is linked to ~92% lower rate of LV dilation at 1 month.
Why the study?
The relation between infarct artery perfusion and changes in left ventricular volume and function after a first myocardial infarction was unclear.
Does perfusion of the infarct-related artery prevent left ventricular dilation in patients with a first myocardial infarction not receiving thrombolytic therapy?
Population
40 patients with first myocardial infarction without thrombolytic therapy
Comparison
Patients with perfused infarct artery vs patients without perfusion
Design
Observational study with coronary angiography and radionuclide angiograms
Follow-up
1 month
Authors
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Patency of the infarct-related artery after myocardial infarction is a major determinant of subsequent left ventricular remodeling and prevents ventricular dilation.
Cohort (n=40)
Does perfusion of the infarct-related artery prevent left ventricular dilation in patients with a first myocardial infarction not receiving thrombolytic therapy?
Absolute Event Rate: 7.7% vs 100%
Patency of the infarct-related artery after myocardial infarction is a major determinant of subsequent left ventricular remodeling and prevents ventricular dilation.
Jeremy et al. (1987) conducted a cohort in Acute myocardial infarction (n=40). Perfusion of the infarct-related artery vs. No perfusion of the infarct-related artery was evaluated on Left ventricular dilation (≥20% increase in volume). Perfusion of the infarct-related artery was associated with a lower rate of left ventricular dilation at 1 month compared to no perfusion (7.7% vs 100%).
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