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Current clinical diagnoses of depression are generally confounded by comorbid anxiety, leading to confusion about core mechanisms. This paper proposes the concept of "pure depression," defined as a low-energy state centered on anhedonia and reduced motivation, without significant anxiety-related somatic symptoms. From an evolutionary functional perspective, this paper re-derives the mechanistic relationship between depression and anxiety, and derives ten corollaries concerning symptom separation, negative feedback regulation, PTSD triggering, and personality formation.
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Cheng You (2026) studied this question.
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