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A method for the direct synthesis of 3,3-difluoro-9-azatricyclo[3.3.1.02,4]nonanes via a (5 + 2) cycloaddition between a gem-difluorocyclopropene and an oxidopyridinium ion is reported. This approach furnishes the products in moderate to good yields, with exclusive exo-selectivity and broad substrate compatibility. Its synthetic utility is further demonstrated by a gram-scale reaction and derivatization studies.
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Liu et al. (2026) studied this question.
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