Reports successful treatment of persistent Trichosporon mediastinitis after infant cardiac surgery using voriconazole and omental flap closure, highlighting challenges in fungal infection clearance.
mediastinitis in a 4-month-old male infant after repair of total anomalous pulmonary venous return. The causative organism was identified by genetic sequence analysis. Despite standard debridement and negative-pressure wound therapy, positive cultures persisted. Daily irrigation plus voriconazole therapy was required to achieve culture negativity. Chest closure was performed using omental filling, and the infant recovered without recurrence, underscoring the unique challenges of fungal mediastinitis.
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Masaki et al. (2026) studied this question.
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