Key result
Among older adults with atrial fibrillation, high-dose inactivated influenza vaccine did not significantly reduce the primary endpoint of hospitalization for influenza or pneumonia compared to standard-dose vaccine (rVE -13.5%).
Why the study?
Individuals with atrial fibrillation face heightened risk of influenza-related complications, but effectiveness of high-dose influenza vaccine against cardiorespiratory events in older adults with AF remains unexplored in trials powered to assess hospitalizations.
Does high-dose inactivated influenza vaccine reduce hospitalizations for influenza or pneumonia compared to standard-dose vaccine in older adults with atrial fibrillation?
RCT (n=332,438)
Open-label
1:1
Yes
Does high-dose inactivated influenza vaccine reduce hospitalizations for influenza or pneumonia compared to standard-dose vaccine in older adults with atrial fibrillation?
In older adults with atrial fibrillation, high-dose influenza vaccine did not significantly reduce the primary endpoint of influenza or pneumonia hospitalization compared to standard-dose vaccine, but was associated with consistent reductions in cardiorespiratory and cardiovascular hospitalizations.
Answers are grounded in this paper and cite their sources.
High-dose vaccine is not superior for preventing influenza or pneumonia hospitalizations in older adults with AF; confirms no effect modification by AF status.
I ndividuals with atrial fibrillation (AF) face a heightened risk of influenza-related complications, including respiratory 1 and cardiovascular 2 events, mortality, 1 and AF onset.3 The high-dose inactivated influenza vaccine (HD-IIV) has demonstrated superior efficacy against influenza infection vs standard-dose inactivated influenza vaccines (SD-IIVs) among older adults in a double-blind ran-domized trial.4 However, effectiveness of HD-IIV against cardiorespiratory events in older adults with AF remains unexplored in trials powered to assess hospitalizations.The DANFLU-2 (A Pragmatic Randomized Trial to Evaluate the Effectiveness of High-Dose Influenza Vaccine vs Standard-Dose Influenza Vaccine in Older Adults; NCT05517174) trial demonstrated reductions
No takes yet. Share an insight, caveat, or question.
Espersen et al. (2025) conducted an RCT in Atrial Fibrillation (n=332,438). High-dose inactivated influenza vaccine vs. Standard-dose inactivated influenza vaccine was evaluated on Hospitalization for influenza or pneumonia (rVE -13.5%, 95% CI -35.5 to 4.8). Among older adults with atrial fibrillation, high-dose inactivated influenza vaccine did not significantly reduce the primary endpoint of hospitalization for influenza or pneumonia compared to standard-dose vaccine (rVE -13.5%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: