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A total of 153 rabbits had their legs exposed to temperatures of −25°C or −15°C for 30 minutes and subsequently treated with heparin administered intravenously for a period of 6 days. Twelve animals received 20 mg of heparin every 4 hours. 39 received 30 mg every 12 hours, and 102 received 30 mg every 6 hours.
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Pichotka et al. (1949) studied this question.
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