Key result
Hypertension is a major independent risk factor for HFpEF pathogenesis, accounting for a higher population-attributable risk than obesity in certain cohorts.
This viewpoint emphasizes the established role of hypertension in HFpEF pathogenesis, suggesting it should not be overshadowed by the adipokine hypothesis of obesity.
hypothesis may vary across populations, potentially having greater applicability in North American cohorts.
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Neto et al. (2026) conducted an editorial in Heart failure with preserved ejection fraction (HFpEF). Obesity and adipokines vs. Hypertension was evaluated. Hypertension is a major independent risk factor for HFpEF pathogenesis, accounting for a higher population-attributable risk than obesity in certain cohorts.
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