Key result
ACE2 protein expression was detected in 28.0% of analyzed tumors across 83 of 119 tumor types, most frequently in renal cell and colorectal carcinomas.
Why the study?
The expression pattern and potential biological relevance of ACE2 protein across a wide range of human tumour types were not comprehensively characterized.
Cross-Sectional (n=15,914)
Yes
Answers are grounded in this paper and cite their sources.
Angiotensin-converting enzyme 2 (ACE2) is a regulator in the renin-angiotensin system. ACE2 expression was analysed immunohistochemically in 15,306 samples from 119 tumour types and in 608 samples of 76 normal tissue types. In normal tissue, ACE2 was most abundant in testis and corpus luteum, kidney, small intestine and capillaries of selected organs. At least an occasional weak ACE2 positivity of tumour cells was seen in 83 of 119 (70%) tumour types. ACE2 tumour cell positivity was particularly frequent in papillary (94%) and clear cell (86%) renal cell carcinoma, colorectal adenocarcinoma (81%), mucinous ovarian cancer (61%), cholangiocarcinoma (58%), hepatocellular carcinoma (56%), and in adenocarcinomas of the stomach (47%), pancreas (42%), and the lung (35%). ACE2-positive capillaries were found in 409/12,644 (3%) of analysable tumours, most frequently in tumours with endocrine/neuroendocrine activity. Presence of ACE2-positive capillaries was linked to low stage in papillary thyroid cancer and low grade in neuroendocrine neoplasms. In conclusion, ACE2 expression can occur both in tumour cells and tumour-associated capillaries in a broad variety of different tumour types at highly variable frequencies.
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Meiners et al. (2021) conducted a cross-sectional in Human tumors (119 types) (n=15,914). ACE2 protein expression vs. ACE2 negative tumors was evaluated on Positive ACE2 immunostaining in tumor cells. ACE2 protein expression was detected in 28.0% of analyzed tumors across 83 of 119 tumor types, most frequently in renal cell and colorectal carcinomas.
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