Key result
Abdominal obesity drives cardiometabolic risk and underlies the development of metabolic syndrome.
Why the study?
Abdominal obesity is a key component of metabolic syndrome and a major risk factor for metabolic and cardiovascular diseases, but its mechanisms and clinical implications require comprehensive review.
Answers are grounded in this paper and cite their sources.
This review highlights the central role of visceral adipose tissue as an active endocrine organ driving metabolic syndrome and cardiometabolic risk.
Abdominal obesity is recognized as one of the most important components of metabolic syndrome and a major risk factor for numerous metabolic and cardiovascular diseases. Excessive accumulation of visceral adipose tissue contributes to the development of insulin resistance, dyslipidemia, hypertension, impaired glucose metabolism, and chronic low-grade inflammation. This article reviews current scientific concepts regarding the epidemiology, pathophysiology, clinical significance, diagnosis, and management of abdominal obesity. Particular attention is given to the role of visceral fat as an active endocrine organ that produces various adipokines and inflammatory mediators influencing metabolic homeostasis. Recent evidence indicates that abdominal obesity is more strongly associated with cardiometabolic risk than general obesity and serves as a central mechanism in the development of metabolic syndrome. Early identification through anthropometric assessment and appropriate preventive measures may significantly reduce the burden of obesity-related complications. Lifestyle modification remains the cornerstone of treatment, while pharmacological and surgical interventions may be considered in selected cases. Understanding the mechanisms and consequences of abdominal obesity is essential for improving prevention and treatment strategies.
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Avazova et al. (2026) conducted a review in Abdominal obesity and metabolic syndrome. Abdominal obesity was evaluated. Abdominal obesity is strongly associated with cardiometabolic risk and serves as a central mechanism in the development of metabolic syndrome.
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