UV irradiation of cells causes the formation of genotoxic pyrimidine dimer DNA lesions, which are repaired in vivo by various repair enzymes. The synthesis, X-ray crystal structure, and incorporation into oligonucleotides of the lesion analogue 1 are described. Analysis of the reparability of oligonucleotides containing 1 with various DNA photolyase repair enzymes shows the efficient repair of such oligonucleotides, which proves that 1 is a useful tool for the investigation of DNA repair processes on a molecular level.
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Butenandt et al. (1998) studied this question.