Normal Saline for Kidney Transplantation Surgery: Less Is More

Editorial| October 2021 Normal Saline for Kidney Transplantation Surgery: Less Is More This article has an Audio Podcast Duminda N. Wijeysundera, M.D., Ph.D.; Duminda N. Wijeysundera, M.D., Ph.D. From the Department of Anesthesia, and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada; the Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Canada; Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Canada Search for other works by this author on: This Site PubMed Google Scholar Stuart A. McCluskey, M.D., Ph.D. Stuart A. McCluskey, M.D., Ph.D. the Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Canada; the Department of Anesthesia and Pain Management, and Multiorgan Transplant Program, University Health Network, Toronto, Canada Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information This editorial accompanies the article on p. 621. Accepted for publication July 22, 2021. Address correspondence to Dr. Wijeysundera: Anesthesiology October 2021, Vol. 135, 564–567. https://doi.org/10.1097/ALN.0000000000003948 Connected Content Article: Perioperative Normal Saline Administration and Delayed Graft Function in Patients Undergoing Kidney Transplantation: A Retrospective Cohort Study Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Search Site Citation Duminda N. Wijeysundera, Stuart A. McCluskey; Normal Saline for Kidney Transplantation Surgery: Less Is More. Anesthesiology 2021; 135:564–567 doi: https://doi.org/10.1097/ALN.0000000000003948 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll PublicationsAnesthesiology Search Advanced Search Topics: normal saline, renal transplantation, surgery specialty, surgical procedures, operative By 2030, 1 million people in the United States will have end-stage renal disease.1 Kidney transplantation is a critically important intervention for these individuals: transplantation improves survival, quality of life, and healthcare costs compared to maintenance dialysis.2–5 Regrettably, the supply of transplantable organs remains inadequate.6 Hence, optimization of the short-term and long-term function of transplanted kidneys is critically important. Transplanted kidneys are vulnerable to acute kidney injury (AKI) related to hemodynamic instability,7 hypovolemia,8 immunologic injury, and ischemia-reperfusion injury.9 After 25 to 30% of deceased donor kidney transplantation procedures in the United States, such perioperative AKI leads to delayed graft function,10 which is typically defined as the need for dialysis within a week after transplantation.9 This incidence is likely to increase even further with increased reliance on marginal kidneys from expanded criteria donors or donation after circulatory death. Delayed graft function has important... You do not currently have access to this content.