The palladium-catalyzed ureidation reaction of 2-chloropyridines can be regioselectively performed in good yield, with both aryl and aliphatic ureas, using xantphos as the ligand, Pd(OAc)2 as the source of palladium, NaOt-Bu/H2O or NaOH/H2O as the base, and dioxane as the solvent
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Abad‐Somovilla et al. (2005) studied this question.