SUMMARY.— Six out of 7 consecutive patients seen in the last 4 years suffering from generalized pustular psoriasis (von Zumbusch) have had the pustular phase terminated by a 6 weeks course of systemic antibiotic treatment directed against the coagulase positive staphylococci found on blood culture. Antibiotics to which the isolates were insensitive proved ineffective. The unsuccessful (fatal) case was seen in retrospect to have had inappropriate antibiotic treatment. Two of the patients relapsed but their pustulation was again terminated by the same means. These results were achieved without using methotrexate or systemic corticosteroids. It is suggested that suitable systemic antibiotics offer the safest means of treating this serious form of psoriasis.
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McFadyen et al. (1971) studied this question.