The flavonoid naringin was found to induce the expression of hrmA, a gene with a symbiotic phenotype in the cyanobacterium Nostoc punctiforme. A comparative analysis of several flavonoids revealed the 7-O-neohesperidoside, 4'-OH, and C-2-C-3 double bond in naringin as structural determinants of its hrmA-inducing activity.
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Hideo Yamasaki (2000) studied this question.
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