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Significance Gene drive can spread beneficial traits through populations, but will never be a one-shot project in which one genetic element provides all desired modifications, for an indefinitely long time. Here, we show that gene drive-mediated population modification in Drosophila can be overwritten with new content while eliminating old, using Cleave and Rescue ( ClvR ) selfish genetic elements. The ability to carry out cycles of modification that create and then leave behind a modest genetic footprint while entering and exiting a population provides important points of control. It makes possible the replacement of broken elements, upgrades with new elements that better carry out their tasks, and/or provide new functions, all while promoting the removal of modifications no longer needed.
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Oberhofer et al. (2020) studied this question.
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