Key result
Lower total cholesterol linked to ~53% higher risk of agitation in treatment-resistant schizophrenia.
Why the study?
The relation between total cholesterol levels and cognition in old age, including the need to separate between-person from within-person associations, was unclear.
Cross-Sectional (n=280)
No
Odds Ratio: 0.47 (95% CI 0.23–0.95)
Absolute Event Rate: 4.08% vs 4.68%
p-value: p=0.023
Cohort study reveals that steeper cholesterol decline tracks faster cognitive decline in older adults, suggesting falling cholesterol levels in late life are linked to dementia pathologies.
= 127), the data suggested a linear trend, indicating that lower TC values were associated with poorer cognition. TC levels declined over time in the vast majority (96%), and the steepness of this decline was associated with the rate of cognitive decline. This within-person association was particularly strong among incident dementia cases with low TC values. Our findings indicate an optimal range of TC values associated with better cognition in old age and that the within-person association between TC and cognition is related to dementia pathologies. Further, our findings demonstrate the need to separate between-person from within-person associations when evaluating the relation between TC and cognition in old age. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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Thorvaldsson et al. (2020) conducted a cross-sectional in Treatment-Resistant Schizophrenia (TRS) with or without agitation/excitement (n=280). Total cholesterol (TC) levels vs. Higher TC levels was evaluated on Risk of agitation/excitement associated with total cholesterol levels (OR 0.47, 95% CI 0.23-0.95, p=0.023). Lower total cholesterol levels were significantly associated with a higher risk of agitation and excitement in male patients with treatment-resistant schizophrenia (OR 0.47).
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