In vivo and in vitro absorption and binding to powdered stratum corneum as methods to evaluate skin absorption of environmental chemical contaminants from ground and surface water

The objectives of this study were to compare methods to determine the binding and absorption of water contaminants to skin, to examine linearity of response, and to determine whether skin was an environmental route for water contaminants to enter the body. The three chemical examined were (/sup 14/C)-p-nitroaniline (10.1 mCi/mM), (/sup 14/C)benzene (56 mCi/mM, and /sup 14/C-labeled 54% PCB (32 mCi/mM). The chemical were added to distilled water and the concentration in water was determined by liquid scintillation counting.