Key result
Young CKD patients exhibit ~28% higher carotid intima-media thickness versus healthy controls.
Why the study?
Chronic kidney disease is associated with accelerated atherosclerosis in younger populations, but traditional markers often fail to detect early subclinical vascular changes.
Does B-mode ultrasonography detect increased carotid and femoral intima-media thickness as markers of preclinical atherosclerosis in young patients with chronic kidney disease compared to healthy controls?
Observational (n=50)
No
Does B-mode ultrasonography detect increased carotid and femoral intima-media thickness as markers of preclinical atherosclerosis in young patients with chronic kidney disease compared to healthy controls?
Absolute Event Rate: 0.69% vs 0.54%
p-value: p=0.001
Ultrasonographic measurement of carotid and femoral intima-media thickness reveals early subclinical atherosclerosis in young patients with CKD, correlating with renal decline and dyslipidemia.
Supports early atherosclerosis in young CKD; leaves open prognostic value and need for outcome trials before clinical adoption.
Background:Chronic kidney disease (CKD) is associated with accelerated atherosclerosis, even in younger populations. Traditional markers often fail to detect subclinical vascular changes early. This study evaluated the role of carotid and femoral intima-media thickness (cIMT, fIMT) as non-invasive markers of preclinical atherosclerosis in adolescent and young adult CKD patients. Methods:A prospective observational study was conducted involving 50 participants (25 CKD patients and 25 age- and sex-matched controls). Demographic, clinical, and biochemical parameters were recorded. B-mode ultrasonography was used to assess cIMT and fIMT bilaterally. Data were analyzed using t-tests, Pearson correlation, and multivariate regression. Results:CKD patients exhibited significantly higher cIMT (0.69 ± 0.06 mm) and fIMT (0.78 ± 0.07 mm) compared to controls (p<0.001). IMT correlated positively with serum creatinine, LDL, and triglycerides and negatively with eGFR. Multivariate regression identified serum creatinine and LDL as independent predictors of increased IMT. Conclusion:Increased cIMT and fIMT in young CKD patients reflect early vascular remodeling. Ultrasonographic IMT measurement is a sensitive and practical tool for early cardiovascular risk assessment in this vulnerable group.
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Ramana et al. (2025) conducted an observational in Chronic kidney disease (n=50). Chronic kidney disease vs. Healthy controls was evaluated on Carotid intima-media thickness (cIMT) (p=0.001). Adolescents and young adults with chronic kidney disease exhibited significantly higher carotid (0.69 vs 0.54 mm) and femoral (0.78 vs 0.62 mm) intima-media thickness compared to healthy controls.
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