Key result
Aortic banding increases myocardial amino acid transport during early hypertrophy in rat hearts.
Why the study?
Myocardial amino acid transport activity in experimental cardiac hypertrophy was investigated to understand its relation to tissue growth activity.
p-value: p=<0.01
Hypothesis-generating for amino acid transport in pressure-overload hypertrophy; requires human validation before clinical consideration.
Myocardial amino acid transport activity was estimated in experimental cardiac hypertrophy with an aid of a nonmetabolized amino acid analogue, C14-α-aminoisobutyric acid (C14-AIB). Myocardial AIB uptake was lower than the reported value for skeletal muscle and decreased linearly with increasing heart weight. These differences were discussed in relation to tissue activity to grow. With banding the aorta, myocardial AIB uptake increased within 3.5 days, but only in hearts which have hypertrophied significantly.
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KOIDE et al. (1971) studied Experimental cardiac hypertrophy. Aortic constriction (banding) vs. Sham-operated control was evaluated on Myocardial C14-AIB uptake (amino acid transport) (p=<0.01). Experimental aortic banding in rats significantly increased myocardial amino acid transport (C14-AIB uptake) within 3.5 days in hearts that developed significant hypertrophy.
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