Key result
Baseline depressive symptom severity is linked to ~17% higher odds of discharge antidepressant use post-stroke.
Why the study?
Individual determinants of antidepressant treatment and outpatient rehabilitation after ischemic stroke were not well characterized.
Observational (n=303)
Yes
Odds Ratio: 1.17 (95% CI 1.05–1.3)
p-value: p=<0.01
Depressive symptom screening may inform post-stroke antidepressant decisions; hypothesis-generating for outcome impact.
This study aims to identify individual determinants of antidepressant treatment and outpatient rehabilitation after stroke. People with ischemic stroke ( N = 303) recruited at 2 inpatient rehabilitation clinics were included into a prospective longitudinal study with follow-up telephone interviews 6 and 12 months later. Participants reported on their use of antidepressant medication and psychotherapy as well as physical, occupational, speech, and neuropsychological therapy. The use of antidepressants at discharge ( n = 65, 23.8%) was predicted by the severity of depressive symptoms, severity of stroke, history of depression, and use of antidepressants at admission (all p < .05, R 2 = .55). The number of outpatient rehabilitation services used at follow-ups was predicted by higher functional and cognitive impairment, higher education, younger age, severity of depressive symptoms, and lower self-efficacy (all p < .05; R 2 6M = .24, R 2 12M = .49). The relevance of identified determinants for the improvement of treatment rates after stroke is discussed.
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Ladwig et al. (2020) conducted an observational in Ischemic stroke (n=303). Severity of depressive symptoms vs. Lower severity of depressive symptoms was evaluated on Use of antidepressant medication at discharge (OR 1.17, 95% CI 1.05-1.30, p=<0.01). Higher severity of depressive symptoms at baseline significantly predicted the use of antidepressant medication at discharge after stroke (OR 1.17).
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