Why the study?
Some antidepressants are associated with QTc prolongation, but the magnitude and clinical implications of this association are uncertain.
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According to a recent cross-sectional study, some antidepressants, including amitriptyline, citalopram and escitalopram, are associated with QTc prolongation. However, the magnitude of this association is relatively small, and the clinical implications uncertain. In this article, the main strengths and weaknesses of this cross-sectional study are briefly analysed alongside recent warnings issued by regulatory authorities. Implications for research and practice are discussed.
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Nosè et al. (2013) conducted an editorial in Antidepressant use (n=38,397). Citalopram, escitalopram, and amitriptyline vs. Lower doses or other antidepressants was evaluated on QTc interval prolongation (mean QTc increase 10.3 ms (citalopram 20 to 40 mg)).
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