Key result
Genetically predicted neuroticism fails to increase coronary artery disease risk despite mood swing associations.
Why the study?
Somatic manifestations of psychological distress, particularly neuroticism, may influence the recognition and diagnosis of coronary artery disease and chest pain symptoms.
Observational (n=184,305)
Odds Ratio: 1.12 (95% CI 0.95–1.33)
p-value: p=0.187
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Neuroticism should not yet inform CAD risk stratification; leaves open whether mood swings warrant targeted investigation in prospective studies.
Paul T. Costa (1987) conducted an observational in Coronary artery disease (n=184,305). Genetically predicted neuroticism vs. Lower genetic liability to neuroticism was evaluated on Coronary artery disease (OR 1.12, 95% CI 0.95-1.33, p=0.187). Genetically predicted neuroticism had no significant causal effect on the risk of coronary artery disease (OR 1.12), although the specific trait of experiencing mood swings was associated with an increased risk.
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