Pyridoxine-Responsive Anemia with Neuropathy

Case Studies1 November 1963Pyridoxine-Responsive Anemia with NeuropathyEUGENE M. BEAUPRE, M.D., PATRICK M. GROWNEY, M.D.EUGENE M. BEAUPRE, M.D.Search for more papers by this author, PATRICK M. GROWNEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-5-724 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPyridoxine-responsive anemia was first reported in a human adult by Harris, Whittington, Weisman, Jr., and Horrigan (1) in 1956. Since then a number of individual cases have been described (2-15) and several excellent reviews have been published (6, 9, 10, 14). Only 4 females with this condition have been reported (13, 14, 16, 17). This excludes Maier's case report (18), in 1957, of a female patient with a macrocytic megaloblastic anemia responsive to vitamin B6 therapy, which is unlike that of any of the group described subsequently that responded to pyridoxine therapy.The case report below is that of a...References1. HARRISWHITTINGTONWEISMANHORRIGAN JWRMRDL: Pyridoxine-responsive anemia in the human adult. Proc. Soc. Exp. Biol. Med. 91: 427, 1956. CrossrefMedlineGoogle Scholar2. FOYKONDI HA: Hypochromic anemias of the tropics associated with pyridoxine and nicotinic acid deficiency. Blood 13: 1054, 1958. CrossrefMedlineGoogle Scholar3. BISHOPBETHELL RCFH: Hereditary hypochromic anemia with transfusion hemosiderosis treated with pyridoxine: report of a case. New Eng. J. Med. 261: 486, 1959. CrossrefMedlineGoogle Scholar4. ERSLEVLEARCASTLE AJAAWB: Pyridoxine-responsive anemia. New Eng. J. Med. 262: 1209, 1960. CrossrefMedlineGoogle Scholar5. VERLOOPRADEMAKER MCW: Anemia due to pyridoxine deficiency in man. Brit. 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HUNTSTOKESMCCRORYSTROUD ADJWWHH: Pyridoxine dependency: report of a case of intractable convulsions in an infant controlled by pyridoxine. Pediatrics 13: 140, 1954. MedlineGoogle Scholar38. GARTYYONISBRAHAMSTEINITZ RZJK: Pyridoxine-dependent convulsions in an infant. Arch. Dis. Child. 37: 21, 1962. CrossrefMedlineGoogle Scholar39. MARIEHENNEQUETLYONDEBRISLEBALLE JAGPJC: Les crises convulsives pyridoxino-sensibles du Nouveau-ne et du nourrisson. Sem. Hop. Paris 35: 1411, 1959. MedlineGoogle Scholar40. SCRIVER CR: Vitamin B6-dependency and infantile convulsions. Pediatrics 26: 62, 1960. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EUGENE M. BEAUPRE, M.D.; PATRICK M. GROWNEY, M.D.Affiliations: Philadelphia, PennsylvaniaFrom the Hematology Section, Department of Medicine, Hospital of the University of Pennsylvania and School of Medicine, Philadelphia, Pennsylvania.This study was supported in part by grant OG16 from the Clinical Research Center Branch, National Institutes of Health, Bethesda, Maryland.Dr. Beaupre is a Research Fellow of the American College of Physicians, and Dr. Growney is a Daland Research Fellow and former Clinical Fellow of the American Cancer Society.Requests for reprints should be addressed to Eugene M. Beaupre, M.D., Hematology Section of the Medical Clinic, Hospital of the University of Pennsylvania, 3600 Spruce Street, Philadelphia 4, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRevisiting the Evidence for Neuropathy Caused by Pyridoxine Deficiency and ExcessIntroductionPyridoxine-Responsive Hypolipidemia and Hypocholesterolemia in a Patient with Pyridoxine-Responsive AnemiaPyridoxine-Responsive AnaemiasNutrition in Relation to the AnemiasPyridoxine-Responsive Anemia—Prototype and Variations on the ThemeHuman Requirements for Vitamin B6 1 November 1963Volume 59, Issue 5_Part_1Page: 724-730KeywordsAdultsAnemiaHematology and oncologyHospital medicineMegaloblastic anemiaNeuropathyPyridoxine ePublished: 1 December 2008 Issue Published: 1 November 1963 PDF downloadLoading ...