Manuscripts are desk rejected when they do not fit the mission of the journal or are too underdeveloped to benefit from the review process. In such cases, two members of the editorial team go through the manuscript and provide a developmental letter to author or authors to advance the article further. This helps free up the time of editors and reviewers to concentrate on the most promising manuscripts.
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Justin B. L. Craig (2010) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: