Infection with Hepatitis C Virus Genotype 4 Is Associated with a Poor Response to Interferon-α

Letters16 May 2000Infection with Hepatitis C Virus Genotype 4 Is Associated with a Poor Response to Interferon-αHervé Zylberberg, MD, M. L. Chaix, MD, and Christian Bréchot, MD, PhDHervé Zylberberg, MDHôpital Necker; 75747 Paris, France (Zylberberg)Hôpital Necker; 75747 Paris, France (Chaix)Hôpital Necker; 75747 Paris, France (Bréchot), M. L. Chaix, MDHôpital Necker; 75747 Paris, France (Zylberberg)Hôpital Necker; 75747 Paris, France (Chaix)Hôpital Necker; 75747 Paris, France (Bréchot), and Christian Bréchot, MD, PhDHôpital Necker; 75747 Paris, France (Zylberberg)Hôpital Necker; 75747 Paris, France (Chaix)Hôpital Necker; 75747 Paris, France (Bréchot)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-10-200005160-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The hepatitis C virus (HCV) genotype is a crucial predictive factor of response to interferon-α and is associated with the route of infection (1, 2). Although HCV genotype 4 is generally assumed to be resistant to interferon-α therapy, detailed studies on this issue are still lacking (3, 4).We studied 74 (5%) patients infected with HCV genotype 4 out of the 1520 HCV-infected patients in our files who had undergone genotyping. Genotype and quantitative viremia were assessed by the Inno-Lipa (Innogenetics, Zwijnaarde, Belgium) and Monitor (Hoffman-LaRoche, Meylan, France) assays, respectively.The risk factors were blood transfusion in ...References1. Simmonds P, Holmes EC, Cha TA, Chan TA, Chan SW, McOmish F, et al . Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J Gen Virol. 1993;74:2391-9. CrossrefMedlineGoogle Scholar2. Nousbaum JP, Pol S, Nalpas B, Landais B, Berthelot P, Brechot C. Hepatitis C virus type 1b (II) infection in France and Italy: collaborative study group. Ann Intern Med. 1995;122:161-8. LinkGoogle Scholar3. El-Zavadi A, Simmonds P, Dabbous H, Prescott L, Selim O, Adhy A. Response of chronic hepatitis C type 4 Egyptian patients to α-interferon [Abstract]. IASL. 1996; 17T. Google Scholar4. Remy AJ, Verdier E, Perney P, Ducos J, Blanc P, Blanc F, et al . Route of infection, liver histology and response to interferon in patients with chronic hepatitis caused by genotype 4 HCV infection in a western country. J Hepatol. 1998;29:169. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Hôpital Necker; 75747 Paris, France (Zylberberg)Hôpital Necker; 75747 Paris, France (Chaix)Hôpital Necker; 75747 Paris, France (Bréchot) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHepatitis C Virus Genotype 4 and Response to Combination Therapy with Interferon-α2b plus Ribavirin Savino Bruno , Andrea Crosignani , and Giovanni Battista Pinzello Infection with Hepatitis C Virus Genotype 4 Is Associated with a Poor Response to Interferon-α Morris Sherman , George Marinos , and Farhad Sedarati Optimized Virologic Response in Hepatitis C Virus Genotype 4 with Peginterferon-α2a and Ribavirin Moises Diago , Tarek Hassanein , Juan Rodés , Andrew M. 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