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A novel synthetic route for commercial preparation of cinacalcet hydrochloride ( 1 ), a calcimimetic agent and calcium-sensing receptor antagonist, is described. Our synthetic approach involves the preparation of cinacalcet using C–C bond formation catalyzed by iron acetylacetonate/NMP complex with aryl Grignard reagent benzotrifluoride magnesium bromide ( 8 ) and alkenyl halide N -chloropropene naphthylethylamine ( 6 ).
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Tewari et al. (2012) studied this question.
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