Key result
Stable angina pectoris is linked to a significantly reduced short-term fractal scaling exponent versus healthy controls.
Why the study?
The clinical and prognostic significance of fractal dimension and detrended fluctuation analysis in patients with stable angina pectoris without previous myocardial infarction was investigated.
Case-Control (n=45)
No
Fractal HRV measures may aid risk stratification in stable angina; leaves open prognostic utility pending prospective validation.
We investigate the clinical and prognostic significance of fractal dimension and detrended fluctuation analysis by comparing the group of patients with stable angina pectoris without previous myocardial infarction with the group of age-matched healthy controls. The fractal dimension of the R-R series was determined using the rescaled range (R/S) analysis technique. To quantify fractal longe-range-correlation properties of heart rate variability, the detrended fluctuation analysis (DFA) technique was used. The heart rate variability was characterized by a scaling exponent $α$, separately for short-term ($$ 11 beats) time scales. The results of data sets show the existence of crossover phenomena between short-time scales. The short-term fractal scaling exponent was significantly lower in patients with stable angina pectoris.
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Krstačić et al. (2001) conducted a case-control in Stable Angina Pectoris (n=45). Stable angina pectoris vs. Healthy controls was evaluated on Short-term fractal scaling exponent (α1) (p=<0.05). Patients with stable angina pectoris exhibited a significantly lower short-term fractal scaling exponent (0.95 vs 1.08, p<0.05) and higher fractal dimension compared to healthy controls.
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