Amyloidosis Associated with Factor X (Stuart) Deficiency

Case Studies1 August 1964Amyloidosis Associated with Factor X (Stuart) DeficiencyCase ReportLIBERTO PECHET, M.D., JEROME J. KASTRUL, M.D.LIBERTO PECHET, M.D.Search for more papers by this author, JEROME J. KASTRUL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-2-315 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe present report was prompted by the finding of an isolated clotting Factor X (Stuart) deficiency in a patient with amyloidosis of the liver. Because of the apparent rarity of this combination, only three instances having been previously reported (1-3), it was deemed desirable to report this case in detail.CASE REPORTA 53-year-old white male was hospitalized (Veterans Administration Hospital, Boston, Massachusetts) because of pain and swelling of the left knee and groin of 3 weeks' duration, and a 20-pound weight loss. Prior to this illness he had been in good health. The patient denied any bleeding tendency in...References1. KORSAN-BENGTSENHJORTYGGE KPFJ: Acquired Factor X deficiency in a patient with amyloidosis. Thromb. Diath. Haemorrh. 7: 558, 1962. MedlineGoogle Scholar2. MENACHEBOIRIN DP: Deficit acquis en Facteur X chez un malade atteint d'amylose primitive: injection d'une fraction CSB. Nouv. Rev. Franc. Hemat. 2: 868, 1962. Google Scholar3. HOWELL M: Acquired Factor X deficiency associated with systematized amyloidosis: report of a case. Blood 21: 739, 1963. CrossrefMedlineGoogle Scholar4. QUICK AJ: Clinical application of hippuric acid and prothrombin test. Amer. J. Clin. Path. 10: 222, 1940. CrossrefGoogle Scholar5. BACHMANDUCKERTKOLLER FFF: Stuart-Prower factor assay and its clinical significance. Thromb. Diath. Haemorrh., 2: 24, 1958. MedlineGoogle Scholar6. OWRENAAS PAK: Control of dicoumarol therapy and quantitative determination of prothrombin and proconvertin. Scand. J. Clin. Lab. Invest. 3: 201, 1951. CrossrefMedlineGoogle Scholar7. OWREN PA: Prothrombin and accessory factors: clinical significance. Amer. J. Med. 14: 201, 1953. CrossrefMedlineGoogle Scholar8. TISHKOFFPECHETALEXANDER GHLB: Some biochemical and electrophoretic studies of purified prothrombin, Factor VII (Proconvertin) and Factor X (Stuart). Blood 15: 778, 1960. CrossrefMedlineGoogle Scholar9. ALEXANDERLANDWEHR BG: Prothrombin consumption, serum prothrombin activity and prothrombin conversion accelerator in hemophilia and thrombocytopenia. J. Clin. Invest. 28: 1511, 1949. CrossrefMedlineGoogle Scholar10. BIGGSDOUGLAS RAS: The thromboplastin generation test. J. Clin. Path. 6: 23, 1953. CrossrefMedlineGoogle Scholar11. GRAHAMBARROWWYNNE JBEMTR: Stuart clotting defect. III. An acquired case with complete recovery. Hemophilia and Other Hemorrhagic States, The University of North Carolina Press, Chapel Hill, North Carolina, 1959, p. 158. Google Scholar12. REALEAFDAVISKUCINSKIHOILUNDGANS PDRBCLH: Amyloidosis with an unusual bleeding diathesis: observations on the use of epsilon aminocaproic acid. Ann. Intern. Med., 58: 347, 1963. LinkGoogle Scholar13. LEVINE RA: Amyloid disease of the liver. Amer. J. Med. 33: 349, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Medical Research Laboratories of the Yamins Research Laboratory, Beth Israel Hospital, The Departments of Medicine of Harvard Medical School and Boston University School of Medicine, and the Medical Service of the Boston Veterans Administration Hospital, Boston, Massachusetts.This work was supported in part by research grant HE-0056 from the National Heart Institute, National Institutes of Health, United States Public Health Service, Bethesda, Maryland.Requests for reprints should be addressed to Liberto Pechet, M.D., Beth Israel Hospital, 330 Brookline Avenue, Boston 15, Massachusetts. 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WIGGISHOFF, M.D. 1 August 1964Volume 61, Issue 2Page: 315-318KeywordsAmyloidosisHospital medicineInflammationKneesLiverMedical servicesPrevention, policy, and public healthResearch grantsResearch laboratoriesWeight loss Issue Published: 1 August 1964 PDF DownloadLoading ...