Why the study?
Diagnosis of coronary artery disease with a normal resting ECG is aided by tests creating relative myocardial hypoxemia, but optimal methods remain to be established.
Early CAD diagnostic tests with normal ECG remain inconclusive; leaves open their clinical role pending controlled validation.
THE DIAGNOSIS of coronary artery disease in the presence of a normal resting electrocardiogram has been aided by the use of tests designed to create a relative hypoxemia of the myocardium, the best known of which are the Master two-step test1and the anoxemia test of Levy.2The former method relies upon a standardized amount of exercise based on age, weight, and sex to create a greater demand for oxygen by the myocardium, whereas the anoxemia test decreases the amount of oxygen to the heart through the inhalation of a 10% oxygen mixture for a 20-minute period. The electrocardiographic changes which occur with these procedures in the presence of coronary disease are reflected mainly by RS-T segment depressions and/or T wave inversions in one or several leads. These alterations are similar in both tests and are thought to be due to factors common to the effects of exercise
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HOWARD E. TEWELL (1952) conducted a review in Coronary artery disease. Controlled hypoxemia test was evaluated.
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