Reported herein is the case of a 65‐year‐old man who had completely flat and small squamous cell carcinoma in the esophagus. The subtle lesion was initially detected as a brownish area depicted by non‐magnified endoscopy with the narrow‐band imaging system (NBI). The lesion was predicted to be type 0‐IIb mucosal cancer due to assessment of morphologic change of intrapapillary capillary loop under magnified NBI observation. Endoscopic mucosal resection was performed for the lesion. The histological finding of the removed specimen indicated mucosal squamous cell carcinoma. Endoscopic observation with the NBI system was useful for detecting obscure squamous cell carcinoma and predicting the histological finding.
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Goda et al. (2006) studied this question.