Key result
Grade 1 breast cancer linked to ~12-fold higher odds of positive ANGPTL4 expression vs grade 3.
Why the study?
Invasive breast carcinoma is more aggressive with higher mortality and worse prognosis in younger patients, necessitating biomarker identification.
Cross-Sectional (n=75)
Blinded to clinicopathological data
No
Answers are grounded in this paper and cite their sources.
The grade-ANGPTL4 association in young women requires confirmation in independent cohorts; does not support immediate changes to breast cancer evaluation or therapy.
Biomarker identification is imperative for invasive breast carcinoma, which is more aggressive and associated with higher mortality and worse prognosis in younger patients (<45 years) than in older patients (>50 years). The current study aimed to investigate angiopoietin-like protein 4 (ANGPTL4) and insulin-like growth factor-1 (IGF-1) protein expression in breast tissue from young patients with breast carcinoma. Immunohistochemical staining was applied in formalin-fixed, paraffin-embedded samples of breast carcinoma tissue from young patients aged <45 years at the time of diagnosis. Both proteins were expressed in the majority of cases. The highest frequency of positive ANGPTL4 and IGF-1 expression was observed in the luminal A subtype, whereas the HER2-overexpression subtype exhibited the lowest expression frequency for both proteins. There was no significant association between ANGPTL4 (p = 0.897) and IGF-1 (p = 0.091) expression and molecular subtypes of breast carcinoma. The histological grade was a significant predictor of ANGPTL4 expression (grade 1 vs. grade 3, adjusted odds ratio = 12.39, p = 0.040). Therefore, ANGPTL-4 and IGF-1 expressions are common in young breast carcinoma tissue. There is a potential use of them as biomarkers in breast carcinoma.
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Kamaludin et al. (2022) conducted a cross-sectional in Invasive breast carcinoma (n=75). Histological grade 1 vs. Histological grade 3 was evaluated on Positive ANGPTL4 expression (adjusted OR 12.39, p=0.040). In young women with invasive breast carcinoma, histological grade 1 was associated with a 12.39-fold higher odds of positive ANGPTL4 expression compared to grade 3 tumors.
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