Key result
Vasospastic angina is linked to ~2-fold higher basal coronary tone at nonspastic arterial sites.
Why the study?
Previous studies were inconclusive whether basal coronary artery tone is elevated at spasm-related and non-spasm-related arteries in patients with vasospastic angina and whether insulin resistance syndrome correlates to vasospastic angina and basal coronary artery tone.
Case-Control (n=48)
Elevated basal tone marks higher vasospastic activity; leaves open any link to insulin resistance or hyperinsulinemia.
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Doo et al. (1997) conducted a case-control in Vasospastic angina (n=48). Vasospastic angina vs. Atypical chest pain (controls) was evaluated on Basal coronary artery tone at the nonspastic site of the spasm-related artery (percent increase in diameter induced by nitroglycerin) (p=<0.0001). Patients with vasospastic angina had significantly greater basal coronary artery tone at the nonspastic site of the spasm-related artery compared to controls (28.1% vs 13.1%, p<0.0001).
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