Key result
Cardiac rehab aerobic exercise is linked to ~22% higher peak VO2 in stable angina.
Why the study?
A novel cardiac rehabilitation aerobic exercise protocol was developed for CHD patients, but its impact on precise CR for stable angina patients required evaluation.
Does a 12-week cardiac rehabilitation aerobic exercise program improve cardiopulmonary function and biochemical markers in patients with stable angina in coronary heart disease?
Cohort (n=112)
No
Does a 12-week cardiac rehabilitation aerobic exercise program improve cardiopulmonary function and biochemical markers in patients with stable angina in coronary heart disease?
Absolute Event Rate: 18.55% vs 15.17%
p-value: p=<0.01
May support exercise in stable angina management; hypothesis-generating and requires randomized confirmation.
Aims/Background A novel exercise protocol for cardiac rehabilitation aerobic (CRA) has been developed by Hebei Sport University, demonstrating efficacy in patients with coronary heart disease (CHD). The objective of this study was to evaluate the impact of CRA on precise cardiac rehabilitation (CR) for CHD patients presenting with stable angina pectoris. Methods The study cohort comprised patients with stable angina who were categorized into three groups: the CRA group (n = 35), the power bicycles (PB) group (n = 34), and the control group (n = 43). In addition to standard treatment, the CRA group underwent a 12-week CRA-based CR intervention, while the PB group participated in a similar program centered on PB exercise, and the control group received only standard treatment. Results At the end of the 12-week intervention, significant differences were observed among the groups in several physiological parameters, including systolic blood pressure (SBP), fasting blood glucose (FBG), triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), Glycated Haemoglobin (Hb-A1c), peak oxygen uptake (Peak VO 2 ), anaerobic threshold (AT), and Peak VO 2 /heart rate (HR) (p < 0.05). Both the CRA and PB groups showed significant reductions in SBP, FBG, TG, TC, LDL, and Hb-A1c compared to the control group (p < 0.05). Additionally, both groups exhibited significant improvements in Peak VO 2 , AT, and Peak VO 2 /HR (p < 0.05). Intra-group analysis revealed that the CRA group showed significant improvements from baseline to post-intervention in SBP, diastolic blood pressure (DBP), FBG, TG, TC, high-density lipoprotein (HDL), LDL, Hb-A1c, Peak VO 2 , AT, and Peak VO 2 /HR (p < 0.05). Similarly, the PB group demonstrated significant improvements across these parameters (p < 0.05). Conclusion Both CRA and PB exercises are safe and effective for achieving precise CR in patients with CHD. A 12-week CRA intervention, conducted three times per week for 30 minutes per session, significantly improves cardiopulmonary function and biochemical makers in patients with stable angina. These improvements are comparable to those achieved through PB exercise in precise CR.
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Zhou et al. (2025) conducted a cohort in Stable angina pectoris in coronary heart disease (n=112). Cardiac rehabilitation aerobic (CRA) exercise vs. Standard treatment (control) or power bicycles (PB) exercise was evaluated on Peak VO2 (mL/min·kg) at 12 weeks (p=<0.01). A 12-week cardiac rehabilitation aerobic exercise program significantly improved peak oxygen uptake and biochemical markers compared to standard treatment in patients with stable angina.
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