The administration of 6 to 8 Gm. of enteric coated ammonium chloride daily for 7 to 45 days to 6 patients resulted in severe, and in 2 instances nearly fatal, acidosis. Five of the 6 patients had congestive heart failure and one, subacute glomerulonephritis; each of the 5 patients with congestive failure had organic renal disease. The clinical manifestations, differentiation from the low salt syrndrome and the therapy are discussed.
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Sleisenger et al. (1951) studied this question.