Effectiveness of brodalumab in acrodermatitis continua of Hallopeau: A case report

Acrodermatitis continua of Hallopeau (ACH) is a rare, chronic pustolosis involving one or more fingers or toes; the sterile pustules arise on erythematous skin of the distal phalange and are often associated with paronychia (Di Costanzo, Napolitano, Patruno, Cantelli, & Balato, 2014).If left untreated the disease leads to skin atrophy, onychodistrophy, and osteolysis; therefore, ACH has a high negative impact on quality of life of patients (Smith et al., 2019).Although some authors consider ACH as a distinct entity, it is generally considered as a variant of pustular psoriasis.Indeed, it may be associated with mutations in IL36RN, and especially in CARD14 and AP1S3 genes, as reported for pustular psoriasis (Smith et al., 2019).