Katayama Syndrome Without Schistosoma mansoni Eggs

Letters21 May 2019Katayama Syndrome Without Schistosoma mansoni EggsMarijke C.C. Langenberg, MD, Marie-Astrid Hoogerwerf, MD, Jacqueline J. Janse, MSc, Lisette van Lieshout, PhD, Paul L.A.M. Corstjens, PhD, and Meta Roestenberg, MD, PhD, on behalf of the CoHSI clinical trial team*Marijke C.C. Langenberg, MDLeiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.), Marie-Astrid Hoogerwerf, MDLeiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.), Jacqueline J. Janse, MScLeiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.), Lisette van Lieshout, PhDLeiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.), Paul L.A.M. Corstjens, PhDLeiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.), and Meta Roestenberg, MD, PhDLeiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.), on behalf of the CoHSI clinical trial team*Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0438 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Katayama syndrome is a self-limited illness that occurs several weeks after infection with schistosome larvae (cercariae). Its symptoms are typical of an acute inflammatory response.Objective: To provide insight into the cause of Katayama syndrome.Case Report: We exposed 2 human participants to male cercariae of Schistosoma mansoni in an experimental infection that met all applicable laws and regulations, was approved by the Ethical Research Committee of Leiden University Medical Center (study P16.111), and was registered at ClinicalTrials.gov (NCT02755324).The first patient was a healthy 24-year-old medical student with a history of hay fever and mild atopic dermatitis. We ...References1. Ross AG, Vickers D, Olds GR, Shah SM, McManus DP. Katayama syndrome. Lancet Infect Dis. 2007;7:218-24. [PMID: 17317603] CrossrefMedlineGoogle Scholar2. Corstjens PL, Nyakundi RK, de Dood CJ, Kariuki TM, Ochola EA, Karanja DM, et al. Improved sensitivity of the urine CAA lateral-flow assay for diagnosing active Schistosoma infections by using larger sample volumes. Parasit Vectors. 2015;8:241. [PMID: 25896512] doi:10.1186/s13071-015-0857-7 CrossrefMedlineGoogle Scholar3. Utzinger J, Becker SL, van Lieshout L, van Dam GJ, Knopp S. New diagnostic tools in schistosomiasis. Clin Microbiol Infect. 2015;21:529-42. [PMID: 25843503] doi:10.1016/j.cmi.2015.03.014 CrossrefMedlineGoogle Scholar4. Janse JJ, Langenberg MCC, Kos-Van Oosterhoud J, Ozir-Fazalalikhan A, Brienen EAT, Winkel BMF, et al. Establishing the production of male Schistosoma mansoni cercariae for a controlled human infection model. J Infect Dis. 2018;218:1142-6. [PMID: 29905805] doi:10.1093/infdis/jiy275 CrossrefMedlineGoogle Scholar5. Rocha MO, Greco DB, Pedroso ER, Lambertucci JR, Rocha RL, Rezende DF, et al. Secondary cutaneous manifestations of acute schistosomiasis mansoni. Ann Trop Med Parasitol. 1995;89:425-30. [PMID: 7487229] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Leiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.)Financial Support: Dr. Roestenberg was supported by a Veni grant from The Netherlands Organization for Health Research and Development (ZonMW) and a Gisela Thier Fellowship from Leiden University Medical Center. Drs. Langenberg and Hoogerwerf were supported by a grant from Dioraphte Foundation. The funding sources had no role in collecting, analyzing, interpreting, or reporting the data.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L18-0438.This article was published at Annals.org on 8 January 2019.*Members of the CoHSI clinical trial team who contributed to this work but did not author it are G.J. van Dam, A. van Diepen, C.J. de Dood, C. Feijt, M.S. Ganesh, H. Gerritsma, G. Hardeman, C.H. Hokke, J.P.R. Koopman, J. Kos-van Oosterhoud, Y.C.M. Kruize, P. Meij, A. Ozir-Fazalalikhan, R. van Schuijlenburg, H.H. Smits, P.H. Verbeek-Menken, L.G. Visser, J.J.C. de Vries, B.M.F. Winkel, and M. Yazdanbakhsh. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUnisexual infection with Schistosoma mansoni in mice has the potential to boost the immune response against eggs after challenge infectionImmunological mechanisms involved in macrophage activation and polarization in schistosomiasisEffects of helminths on the human immune response and the microbiomeSex-Specific Modulation of the Host Transcriptome in the Spleen of Schistosoma mansoni-Infected MiceCharacterisation of tetraspanins from Schistosoma haematobium and evaluation of their potential as novel diagnostic markersA 43-Year-Old Male Traveller Returning from Mozambique With Fever and EosinophiliaPublic perceptions on Controlled Human Infection Model (CHIM) studies—a qualitative pilot study from South IndiaAcute Schistosomiasis With a Schistosoma mattheei × Schistosoma haematobium Hybrid Species in a Cluster of 34 Travelers Infected in South AfricaSchistosomes in the Lung: Immunobiology and OpportunityNeglected Tropical Diseases in TravelersCirculating Anodic Antigen (CAA): A Highly Sensitive Diagnostic Biomarker to Detect Active Schistosoma Infections—Improvement and Use during SCOREThird human challenge trial conference, Oxford, United Kingdom, February 6–7, 2020, a meeting reportMoney-oriented risk-takers or deliberate decision-makers: a cross-sectional survey study of participants in controlled human infection trialsA controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnosticsRisk assessment for the implementation of controlled human Schistosoma mansoni infection trials in UgandaRisk assessment for the implementation of controlled human Schistosoma mansoni infection trials in Uganda 21 May 2019Volume 170, Issue 10Page: 732-733KeywordsAntigensEdemaEosinophiliaEosinophilsFeversImmune responseMolecular pathologyPharynxSweatTemperature ePublished: 8 January 2019 Issue Published: 21 May 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...