Key result
Angioscopy detects early carotid stent neointima undetectable by ultrasound, guiding safe antiplatelet de-escalation.
Why the study?
Determining the appropriate timing for antiplatelet drug reduction after carotid artery stenting is challenging due to limitations in detecting neointima formation with standard imaging.
Case Report (n=1)
No
May support angioscopy-guided early DAPT de-escalation after CAS; hypothesis-generating and requires prospective validation.
We report a case in which neointima was confirmed by angioscopy and antiplatelet drug administration was reduced 2 months after carotid artery stenting (CAS). A patient in their 80s was scheduled to undergo resection for renal cancer; however, he also had right cervical internal carotid artery stenosis. Because this was a risk for general anesthesia, CAS was performed after first starting dual antiplatelet therapy. Urologically, early reduction of antiplatelet drugs was necessary for a nephrectomy. Although no obvious neointima could be identified on ultrasound 2 months after CAS, thin neointima was observed using angioscopy. Based on the above results, we reduced the antiplatelet drug administration, and then the nephrectomy was performed. Ultimately, no cerebral infarction occurred in the perioperative or postoperative periods. Angioscopy allows for visual confirmation of thin neointima. If sufficient neointima can be confirmed, antiplatelet drug reduction can be performed more safely and reliably.
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Fukutome et al. (2023) conducted a case report in Right cervical internal carotid artery stenosis (n=1). Angioscopy-guided antiplatelet drug reduction was evaluated on Confirmation of neointima formation and occurrence of perioperative/postoperative cerebral infarction. Angioscopy successfully visualized thin neointima 2 months after carotid artery stenting that was undetectable by ultrasound, allowing for safe reduction of dual antiplatelet therapy without subsequent cerebral infarction.
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