Total Synthesis of (−)‐Reidispongiolide A, an Actin‐Targeting Marine Macrolide

Actin class: A stereoselective synthesis of the microfilament-destabilizing cytotoxic macrolide (−)-reidispongiolide A, isolated from the marine sponge Reidispongia coerulea, uses a convergent aldol-based strategy to construct the 26-membered macrolactone, followed by a coupling with an N-vinylformamide subunit. This constitutes the first synthesis of any member of the reidispongiolide/sphinxolide family.